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CY-09 is a selective, direct small-molecule inhibitor of the NLRP3 inflammasome that binds the ATP-binding motif of the NLRP3 NACHT domain, inhibiting NLRP3 ATPase activity and suppressing inflammasome assembly and activation. It is supplied as a solid for research use in studies of inflammatory signaling and innate immunity.
Selective NLRP3 inhibitor that binds the NLRP3 ATP-binding motif.
Inhibits NLRP3 ATPase activity to block inflammasome assembly.
Applicable to research on inflammation, innate immunity, and disease models.
Solid, light yellow to yellow appearance; high purity suitable for biochemical assays.
Recommended storage: powder at -20°C for long term stability.
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RK-701 is a highly selective and non-genotoxic inhibitor of G9a (IC50 value of 23-27 nM). It selectively up-regulates HbF, γ-Globin, and BGLT3 expression, while down-regulating H3K9me2 expression. It also inhibits BCL11A and ZBTB7A. This product is intended for research use only.
Highly selective and non-genotoxic G9a inhibitor
Up-regulates HbF, γ-globin, and BGLT3 expression
Down-regulates H3K9me2 expression
Inhibits BCL11A and ZBTB7A
Exhibits antiproliferative activity against human MOLT-4 cells (GI50: 21.3 nM)
Increases proportion of HbF expressing cells
Demonstrates low toxicity
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TNF-alpha/TNFSF2 protein binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR It induces tumor cell death fever cachexia cell proliferation and cell differentiation It also causes insulin resistance and GKAP42 protein degradation in adipocytes Additionally it plays a role in angiogenesis osteoclastogenesis and IL12 production in dendritic cells TNF-alpha/TNFSF2 Protein Cynomolgus (N-His) is the recombinant cynomolgus-derived TNF-alpha/TNFSF2 protein expressed by E coli with N-6 His labeled tag
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Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine[1] TNF alpha binds to its receptors mainly TNFR1 and TNFR2 and then transmits molecular signals for biological functions such as inflammation and cell death[2] TNF alpha stimulates NF- B pathway via TNFR2 promotes cancer growth invasion and metastasis Anti-TNF- MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse[3] TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury[4] TNF-alpha/TNFSF2 Protein Cynomolgus (Biotinylated) is a biotinylated recombinant protein consisting of 157 amino acids (V77-L233) and is produced in E coli
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Hydroxyisohexyl 3-cyclohexene carboxaldehyde is an aldehyde fragrance ingredient used as a hapten probe and analytical reference in research settings. Supplied as a colorless to light-yellow liquid, it is employed in contact allergy studies, patch-testing research, and analytical method development.
Liquid, colorless to light yellow appearance.
Molecular formula C13H22O2; molecular weight 210.31.
Purity 97.8% suitable for analytical and research use.
Available in multiple pack sizes to accommodate laboratory needs.
Serves as a hapten probe in immunological and contact allergy investigations.
Appropriate for reference standard and method development applications.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
TNF-alpha/TNFSF2 protein binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR It induces tumor cell death fever cachexia cell proliferation and cell differentiation It also causes insulin resistance and GKAP42 protein degradation in adipocytes Additionally it plays a role in angiogenesis osteoclastogenesis and IL12 production in dendritic cells TNF-alpha/TNFSF2 Protein Cynomolgus (N-His) is the recombinant cynomolgus-derived TNF-alpha/TNFSF2 protein expressed by E coli with N-6 His labeled tag
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More